Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3921927..3922503 Replicon chromosome
Accession NZ_OU943336
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST305

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag AEG13_RS19405 Protein ID WP_001131963.1
Coordinates 3922216..3922503 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag AEG13_RS19400 Protein ID WP_000063142.1
Coordinates 3921927..3922229 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AEG13_RS19385 (SAMEA1964467_03878) 3918437..3920587 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
AEG13_RS19390 (SAMEA1964467_03879) 3920682..3920885 + 204 WP_000460616.1 YbdD/YjiX family protein -
AEG13_RS19395 (SAMEA1964467_03880) 3920896..3921852 + 957 WP_000187846.1 GTPase -
AEG13_RS19400 (SAMEA1964467_03881) 3921927..3922229 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
AEG13_RS19405 (SAMEA1964467_03882) 3922216..3922503 - 288 WP_001131963.1 BrnT family toxin Toxin
AEG13_RS19410 (SAMEA1964467_03883) 3922756..3923670 - 915 WP_000290515.1 restriction endonuclease -
AEG13_RS19415 (SAMEA1964467_03884) 3923868..3927377 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T294914 WP_001131963.1 NZ_OU943336:c3922503-3922216 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT294914 WP_000063142.1 NZ_OU943336:c3922229-3921927 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References