Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 821847..822472 Replicon chromosome
Accession NZ_OU943336
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST305

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AEG13_RS04030 Protein ID WP_000911334.1
Coordinates 822074..822472 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag AEG13_RS04025 Protein ID WP_000557549.1
Coordinates 821847..822074 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AEG13_RS03995 (SAMEA1964467_00816) 817040..817759 + 720 WP_000082599.1 Rha family transcriptional regulator -
AEG13_RS04000 (SAMEA1964467_00817) 817763..817966 + 204 WP_000184036.1 hypothetical protein -
AEG13_RS04005 (SAMEA1964467_00818) 818049..818504 + 456 WP_223229661.1 hypothetical protein -
AEG13_RS04010 (SAMEA1964467_00819) 818606..819727 + 1122 WP_000028980.1 hypothetical protein -
AEG13_RS04015 (SAMEA1964467_00820) 820338..821144 - 807 WP_077905073.1 DUF1460 domain-containing protein -
AEG13_RS04020 (SAMEA1964467_00821) 821419..821670 - 252 WP_001540858.1 hypothetical protein -
AEG13_RS04025 (SAMEA1964467_00822) 821847..822074 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
AEG13_RS04030 (SAMEA1964467_00823) 822074..822472 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
AEG13_RS04035 (SAMEA1964467_00825) 823279..823815 + 537 WP_001038500.1 STM3031 family outer membrane protein -
AEG13_RS04040 (SAMEA1964467_00826) 823862..824494 + 633 WP_000835268.1 YfdX family protein -
AEG13_RS04045 (SAMEA1964467_00827) 825213..825794 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 814788..832365 17577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T294907 WP_000911334.1 NZ_OU943336:822074-822472 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT294907 WP_000557549.1 NZ_OU943336:821847-822074 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References