Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 299521..300169 Replicon chromosome
Accession NZ_OU943334
Organism Stenotrophomonas maltophilia isolate Stenotrophomonas maltophilia 1800

Toxin (Protein)


Gene name PumA Uniprot ID A0A0L8AET4
Locus tag LNN95_RS01370 Protein ID WP_010486984.1
Coordinates 299521..299808 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LNN95_RS01375 Protein ID WP_099559694.1
Coordinates 299867..300169 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN95_RS01345 (STEN1800_0285) 294719..295450 + 732 WP_197656828.1 type III pantothenate kinase -
LNN95_RS01350 (STEN1800_0286) 295460..296308 + 849 WP_197656827.1 SPOR domain-containing protein -
LNN95_RS01360 (STEN1800_0289) 297537..298661 - 1125 WP_228355032.1 hypothetical protein -
LNN95_RS01365 (STEN1800_0290) 298689..299288 - 600 WP_197656826.1 hypothetical protein -
LNN95_RS01370 (STEN1800_0292) 299521..299808 + 288 WP_010486984.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LNN95_RS01375 (STEN1800_0293) 299867..300169 + 303 WP_099559694.1 putative addiction module antidote protein Antitoxin
LNN95_RS01380 (STEN1800_0294) 300226..300549 - 324 WP_197656825.1 hypothetical protein -
LNN95_RS01385 (STEN1800_0295) 300630..301037 - 408 WP_228355033.1 hypothetical protein -
LNN95_RS01390 (STEN1800_0296) 301632..302402 + 771 WP_197656823.1 DUF3011 domain-containing protein -
LNN95_RS01395 (STEN1800_0297) 302427..302813 - 387 WP_228355034.1 hypothetical protein -
LNN95_RS01400 (STEN1800_0298) 302904..303824 + 921 WP_043401829.1 arginase -
LNN95_RS01405 (STEN1800_0299) 303987..304124 + 138 WP_014035659.1 entericidin A/B family lipoprotein -
LNN95_RS01410 (STEN1800_0300) 304327..304548 + 222 WP_004137109.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 287765..301037 13272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10744.34 Da        Isoelectric Point: 10.8940

>T294903 WP_010486984.1 NZ_OU943334:299521-299808 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAREIARAL

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10789.45 Da        Isoelectric Point: 9.0323

>AT294903 WP_099559694.1 NZ_OU943334:299867-300169 [Stenotrophomonas maltophilia]
MVIKRKVQLKAFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L8AET4

Antitoxin

Source ID Structure

References