Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2049816..2050579 Replicon chromosome
Accession NZ_OU912926
Organism Candidatus Nitrotoga arctica strain 6680 isolate 6680

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MKZ32_RS09335 Protein ID WP_239797022.1
Coordinates 2050085..2050579 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag MKZ32_RS09330 Protein ID WP_239797021.1
Coordinates 2049816..2050088 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ32_RS09315 (NTG6680_1949) 2044943..2047663 + 2721 WP_239797018.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
MKZ32_RS09320 (NTG6680_1950) 2047696..2049480 + 1785 WP_239797019.1 DUF262 domain-containing protein -
MKZ32_RS09325 (NTG6680_1951) 2049521..2049871 + 351 WP_239797020.1 hypothetical protein -
MKZ32_RS09330 (NTG6680_1952) 2049816..2050088 + 273 WP_239797021.1 DUF1778 domain-containing protein Antitoxin
MKZ32_RS09335 (NTG6680_1953) 2050085..2050579 + 495 WP_239797022.1 GNAT family N-acetyltransferase Toxin
MKZ32_RS09340 (NTG6680_1954) 2050591..2050776 - 186 WP_239797023.1 hypothetical protein -
MKZ32_RS09345 (NTG6680_1955) 2050793..2051725 - 933 WP_239797024.1 DUF1853 family protein -
MKZ32_RS09350 (NTG6680_1956) 2051820..2052638 - 819 WP_239797025.1 class I SAM-dependent methyltransferase -
MKZ32_RS09355 (NTG6680_1957) 2052750..2054720 - 1971 WP_239797026.1 acetate--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-147)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18029.78 Da        Isoelectric Point: 8.9068

>T294901 WP_239797022.1 NZ_OU912926:2050085-2050579 [Candidatus Nitrotoga arctica]
MSLQLNAPQPLATTHILDRFECGEGVLDEWLKRRAMVNQMSGASRTFVVADQDSHVYGYYAMAAGAVSHQMATSSVRRNM
PDPVPVMVLARLAVDHHAQGIKLGASLLQDAVNRAVVVSQNAGVRALLVHALHDRAKEFYEHYGFQSSPLHPMTLMLRLN
IGKA

Download         Length: 495 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9829.32 Da        Isoelectric Point: 4.9298

>AT294901 WP_239797021.1 NZ_OU912926:2049816-2050088 [Candidatus Nitrotoga arctica]
MRDAAINLRALPEQRDLIDHAATLLGKNRSDFMLEAACSAAQAVILDQVFFSLNTDKFQQFTAMLDAPPSPNPGLERLMA
VTAPWATVKA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References