Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2049816..2050579 Replicon chromosome
Accession NZ_OU912926
Organism Candidatus Nitrotoga arctica strain 6680 isolate 6680

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MKZ32_RS09335 Protein ID WP_239797022.1
Coordinates 2050085..2050579 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag MKZ32_RS09330 Protein ID WP_239797021.1
Coordinates 2049816..2050088 (+) Length 91 a.a.

Genomic Context

MKZ32_RS09315MKZ32_RS09320MKZ32_RS09325MKZ32_RS09330MKZ32_RS09335MKZ32_RS09340MKZ32_RS09345MKZ32_RS09350MKZ32_RS09355
Location: 2044943..2047663 (2721 bp)
Type: Others
Protein ID: WP_239797018.1
Location: 2047696..2049480 (1785 bp)
Type: Others
Protein ID: WP_239797019.1
Location: 2049521..2049871 (351 bp)
Type: Others
Protein ID: WP_239797020.1
Location: 2049816..2050088 (273 bp)
Type: Antitoxin
Protein ID: WP_239797021.1
Location: 2050085..2050579 (495 bp)
Type: Toxin
Protein ID: WP_239797022.1
Location: 2050591..2050776 (186 bp)
Type: Others
Protein ID: WP_239797023.1
Location: 2050793..2051725 (933 bp)
Type: Others
Protein ID: WP_239797024.1
Location: 2051820..2052638 (819 bp)
Type: Others
Protein ID: WP_239797025.1
Location: 2052750..2054720 (1971 bp)
Type: Others
Protein ID: WP_239797026.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MKZ32_RS09315 (NTG6680_1949)2044943..2047663+2721WP_239797018.1bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase-
MKZ32_RS09320 (NTG6680_1950)2047696..2049480+1785WP_239797019.1DUF262 domain-containing protein-
MKZ32_RS09325 (NTG6680_1951)2049521..2049871+351WP_239797020.1hypothetical protein-
MKZ32_RS09330 (NTG6680_1952)2049816..2050088+273WP_239797021.1DUF1778 domain-containing proteinAntitoxin
MKZ32_RS09335 (NTG6680_1953)2050085..2050579+495WP_239797022.1GNAT family N-acetyltransferaseToxin
MKZ32_RS09340 (NTG6680_1954)2050591..2050776-186WP_239797023.1hypothetical protein-
MKZ32_RS09345 (NTG6680_1955)2050793..2051725-933WP_239797024.1DUF1853 family protein-
MKZ32_RS09350 (NTG6680_1956)2051820..2052638-819WP_239797025.1class I SAM-dependent methyltransferase-
MKZ32_RS09355 (NTG6680_1957)2052750..2054720-1971WP_239797026.1acetate--CoA ligase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-147)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18029.78 Da        Isoelectric Point: 8.9068

>T294901 WP_239797022.1 NZ_OU912926:2050085-2050579 [Candidatus Nitrotoga arctica]
MSLQLNAPQPLATTHILDRFECGEGVLDEWLKRRAMVNQMSGASRTFVVADQDSHVYGYYAMAAGAVSHQMATSSVRRNM
PDPVPVMVLARLAVDHHAQGIKLGASLLQDAVNRAVVVSQNAGVRALLVHALHDRAKEFYEHYGFQSSPLHPMTLMLRLN
IGKA

Download         Length: 495 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9829.32 Da        Isoelectric Point: 4.9298

>AT294901 WP_239797021.1 NZ_OU912926:2049816-2050088 [Candidatus Nitrotoga arctica]
MRDAAINLRALPEQRDLIDHAATLLGKNRSDFMLEAACSAAQAVILDQVFFSLNTDKFQQFTAMLDAPPSPNPGLERLMA
VTAPWATVKA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References