Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1906746..1907344 Replicon chromosome
Accession NZ_OU745373
Organism Cardiobacterium sp. Marseille-Q4385

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LG374_RS09175 Protein ID WP_225757409.1
Coordinates 1906746..1906946 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LG374_RS09180 Protein ID WP_225757410.1
Coordinates 1906949..1907344 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG374_RS09160 1902446..1902979 + 534 WP_225757406.1 hypothetical protein -
LG374_RS09165 1902989..1904422 + 1434 WP_225757407.1 HlyD family type I secretion periplasmic adaptor subunit -
LG374_RS09170 1904582..1906492 - 1911 WP_225757408.1 biosynthetic arginine decarboxylase -
LG374_RS09175 1906746..1906946 + 201 WP_225757409.1 type II toxin-antitoxin system HicA family toxin Toxin
LG374_RS09180 1906949..1907344 + 396 WP_225757410.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LG374_RS09185 1907447..1908094 - 648 WP_225757411.1 glutaredoxin 2 -
LG374_RS09190 1908539..1909549 - 1011 WP_225757412.1 hypothetical protein -
LG374_RS09195 1909578..1910447 - 870 WP_255594492.1 RNase adapter RapZ -
LG374_RS09200 1910556..1911944 + 1389 WP_225757414.1 class II fumarate hydratase -
LG374_RS09205 1912020..1912175 - 156 WP_225757415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-124)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7603.94 Da        Isoelectric Point: 11.8888

>T294886 WP_225757409.1 NZ_OU745373:1906746-1906946 [Cardiobacterium sp. Marseille-Q4385]
MDSKTLIKRLQREGWLLVGGRGDHQKFKHPVIPGQVIVPHPRKDMPIGTLRSIFRQAGWPWPPEGR

Download         Length: 201 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14634.51 Da        Isoelectric Point: 4.5152

>AT294886 WP_225757410.1 NZ_OU745373:1906949-1907344 [Cardiobacterium sp. Marseille-Q4385]
MLYPAFVELGDKNHAYGVVLPDFPGCFSAADEMNDLPARVQEAVELYFEGEDLPLPPPSDLATLRTRPEFAYDGLWMLFD
IDTSRLTTRAKRFNATLPENLLAAIDDYVKTHGGSRSGFLAEAAREKLRSH

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References