Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4901685..4902207 Replicon chromosome
Accession NZ_OU701452
Organism Escherichia coli isolate CNR65D6

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag LWS60_RS23565 Protein ID WP_001105433.1
Coordinates 4901917..4902207 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag LWS60_RS23560 Protein ID WP_000212715.1
Coordinates 4901685..4901927 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS60_RS23540 (4897404) 4897404..4898777 + 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
LWS60_RS23545 (4898927) 4898927..4899478 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
LWS60_RS23550 (4899572) 4899572..4900924 + 1353 WP_001162173.1 metalloprotease PmbA -
LWS60_RS23555 (4901107) 4901107..4901493 + 387 WP_001232246.1 cytochrome b562 -
LWS60_RS23560 (4901685) 4901685..4901927 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LWS60_RS23565 (4901917) 4901917..4902207 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LWS60_RS23570 (4902208) 4902208..4902672 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LWS60_RS23575 (4902852) 4902852..4904990 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
LWS60_RS23580 (4905384) 4905384..4907039 - 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T294881 WP_001105433.1 NZ_OU701452:4901917-4902207 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT294881 WP_000212715.1 NZ_OU701452:4901685-4901927 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References