Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4130191..4130803 Replicon chromosome
Accession NZ_OU701452
Organism Escherichia coli isolate CNR65D6

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag LWS60_RS20010 Protein ID WP_000833473.1
Coordinates 4130618..4130803 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag LWS60_RS20005 Protein ID WP_000499744.1
Coordinates 4130191..4130601 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS60_RS19990 (4125703) 4125703..4126518 - 816 WP_000891823.1 AraC family transcriptional regulator -
LWS60_RS19995 (4126744) 4126744..4128144 + 1401 WP_000204811.1 MFS transporter -
LWS60_RS20000 (4128155) 4128155..4130119 + 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
LWS60_RS20005 (4130191) 4130191..4130601 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LWS60_RS20010 (4130618) 4130618..4130803 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
LWS60_RS20015 (4131072) 4131072..4132610 - 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
LWS60_RS20020 (4132811) 4132811..4133962 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T294877 WP_000833473.1 NZ_OU701452:c4130803-4130618 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT294877 WP_000499744.1 NZ_OU701452:c4130601-4130191 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References