Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3313320..3313974 Replicon chromosome
Accession NZ_OU701452
Organism Escherichia coli isolate CNR65D6

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag LWS60_RS15960 Protein ID WP_000244781.1
Coordinates 3313320..3313727 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag LWS60_RS15965 Protein ID WP_001564007.1
Coordinates 3313708..3313974 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS60_RS15940 (3309277) 3309277..3311010 - 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -
LWS60_RS15945 (3311016) 3311016..3311726 - 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LWS60_RS15950 (3311751) 3311751..3312647 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LWS60_RS15955 (3312759) 3312759..3313280 + 522 WP_001055874.1 flavodoxin FldB -
LWS60_RS15960 (3313320) 3313320..3313727 - 408 WP_000244781.1 protein YgfX Toxin
LWS60_RS15965 (3313708) 3313708..3313974 - 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
LWS60_RS15970 (3314217) 3314217..3315197 + 981 WP_001564008.1 tRNA-modifying protein YgfZ -
LWS60_RS15975 (3315274) 3315274..3315933 - 660 WP_000250274.1 hemolysin III family protein -
LWS60_RS15980 (3316097) 3316097..3316408 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
LWS60_RS15985 (3316453) 3316453..3317886 + 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T294873 WP_000244781.1 NZ_OU701452:c3313727-3313320 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT294873 WP_001564007.1 NZ_OU701452:c3313974-3313708 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References