Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1593471..1594109 Replicon chromosome
Accession NZ_OU701452
Organism Escherichia coli isolate CNR65D6

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag LWS60_RS07575 Protein ID WP_000813795.1
Coordinates 1593471..1593647 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LWS60_RS07580 Protein ID WP_076797675.1
Coordinates 1593693..1594109 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS60_RS07555 (1589093) 1589093..1590304 - 1212 WP_071591517.1 BenE family transporter YdcO -
LWS60_RS07560 (1590357) 1590357..1590893 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
LWS60_RS07565 (1590966) 1590966..1592927 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LWS60_RS07570 (1593019) 1593019..1593249 - 231 WP_023910283.1 YncJ family protein -
LWS60_RS07575 (1593471) 1593471..1593647 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LWS60_RS07580 (1593693) 1593693..1594109 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LWS60_RS07585 (1594188) 1594188..1595594 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
LWS60_RS07590 (1595839) 1595839..1596984 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
LWS60_RS07595 (1597002) 1597002..1598015 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
LWS60_RS07600 (1598016) 1598016..1598957 + 942 WP_106106616.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T294864 WP_000813795.1 NZ_OU701452:1593471-1593647 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT294864 WP_076797675.1 NZ_OU701452:1593693-1594109 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References