Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 957156..957861 Replicon chromosome
Accession NZ_OU701452
Organism Escherichia coli isolate CNR65D6

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag LWS60_RS04460 Protein ID WP_000539521.1
Coordinates 957475..957861 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LWS60_RS04455 Protein ID WP_001280945.1
Coordinates 957156..957485 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS60_RS04440 (952313) 952313..953224 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
LWS60_RS04445 (953402) 953402..955750 + 2349 WP_001550886.1 EAL domain-containing protein -
LWS60_RS04450 (955758) 955758..957086 + 1329 WP_001550887.1 GGDEF domain-containing protein -
LWS60_RS04455 (957156) 957156..957485 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
LWS60_RS04460 (957475) 957475..957861 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LWS60_RS04465 (958087) 958087..959412 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
LWS60_RS04470 (959625) 959625..960008 + 384 WP_000497137.1 biofilm formation regulator BssR -
LWS60_RS04475 (960119) 960119..961234 + 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
LWS60_RS04480 (961231) 961231..961857 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T294856 WP_000539521.1 NZ_OU701452:c957861-957475 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT294856 WP_001280945.1 NZ_OU701452:c957485-957156 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References