Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4572525..4573120 Replicon chromosome
Accession NZ_OU701449
Organism Escherichia coli isolate CNR85I8

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag LWS57_RS22160 Protein ID WP_019842229.1
Coordinates 4572525..4572875 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LWS57_RS22165 Protein ID WP_001223213.1
Coordinates 4572869..4573120 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS57_RS22140 (4567855) 4567855..4568877 - 1023 WP_001550507.1 ABC transporter permease -
LWS57_RS22145 (4568891) 4568891..4570393 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
LWS57_RS22150 (4570525) 4570525..4571481 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LWS57_RS22155 (4571791) 4571791..4572321 + 531 WP_000055075.1 inorganic diphosphatase -
LWS57_RS22160 (4572525) 4572525..4572875 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
LWS57_RS22165 (4572869) 4572869..4573120 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LWS57_RS22170 (4573332) 4573332..4573673 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
LWS57_RS22175 (4573676) 4573676..4577455 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T294850 WP_019842229.1 NZ_OU701449:c4572875-4572525 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT294850 WP_001223213.1 NZ_OU701449:c4573120-4572869 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References