29485

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2862685..2863394 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag CFBS_RS13485 Protein ID WP_003413164.1
Coordinates 2862685..2863098 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CFBS_RS13490 Protein ID WP_003413167.1
Coordinates 2863137..2863394 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS13460 2857739..2858944 - 1206 WP_003413027.1 chorismate synthase -
CFBS_RS13465 2859052..2859366 + 315 WP_009937839.1 hypothetical protein -
CFBS_RS13470 2859662..2860873 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CFBS_RS13475 2861000..2861659 + 660 WP_003902296.1 hypothetical protein -
CFBS_RS13480 2861656..2862318 + 663 WP_003905878.1 hypothetical protein -
CFBS_RS22315 2862315..2862592 + 278 Protein_2622 type II toxin-antitoxin system VapB family antitoxin -
CFBS_RS13485 2862685..2863098 + 414 WP_003413164.1 PIN domain nuclease Toxin
CFBS_RS13490 2863137..2863394 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CFBS_RS13495 2863391..2863768 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CFBS_RS13500 2863784..2864158 - 375 WP_003413177.1 hypothetical protein -
CFBS_RS13505 2864258..2864653 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CFBS_RS13510 2864650..2864895 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CFBS_RS13515 2865306..2865725 - 420 WP_003413190.1 A24 family peptidase -
CFBS_RS13520 2865737..2866546 - 810 WP_003413193.1 shikimate dehydrogenase -
CFBS_RS13525 2866543..2867799 - 1257 WP_014585306.1 endolytic transglycosylase MltG -
CFBS_RS13530 2867792..2868304 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T29485 WP_003413164.1 NC_021251:2862685-2863098 [Mycobacterium tuberculosis CCDC5079]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T29485 NC_021251:2862685-2863098 [Mycobacterium tuberculosis CCDC5079]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT29485 WP_003413167.1 NC_021251:2863137-2863394 [Mycobacterium tuberculosis CCDC5079]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT29485 NC_021251:2863137-2863394 [Mycobacterium tuberculosis CCDC5079]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References