Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3782518..3783136 Replicon chromosome
Accession NZ_OU701449
Organism Escherichia coli isolate CNR85I8

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LWS57_RS18270 Protein ID WP_001291435.1
Coordinates 3782918..3783136 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LWS57_RS18265 Protein ID WP_000344800.1
Coordinates 3782518..3782892 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS57_RS18255 (3777607) 3777607..3778800 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LWS57_RS18260 (3778823) 3778823..3781972 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
LWS57_RS18265 (3782518) 3782518..3782892 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LWS57_RS18270 (3782918) 3782918..3783136 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LWS57_RS18275 (3783308) 3783308..3783859 + 552 WP_000102564.1 maltose O-acetyltransferase -
LWS57_RS18280 (3783975) 3783975..3784445 + 471 WP_000136192.1 YlaC family protein -
LWS57_RS18285 (3784609) 3784609..3786159 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LWS57_RS18290 (3786201) 3786201..3786554 - 354 WP_001550741.1 DUF1428 family protein -
LWS57_RS18300 (3786933) 3786933..3787244 + 312 WP_000409911.1 MGMT family protein -
LWS57_RS18305 (3787275) 3787275..3787847 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T294846 WP_001291435.1 NZ_OU701449:3782918-3783136 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT294846 WP_000344800.1 NZ_OU701449:3782518-3782892 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References