Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3379977..3380682 Replicon chromosome
Accession NZ_OU701449
Organism Escherichia coli isolate CNR85I8

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag LWS57_RS16495 Protein ID WP_000539521.1
Coordinates 3379977..3380363 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LWS57_RS16500 Protein ID WP_001280945.1
Coordinates 3380353..3380682 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS57_RS16475 (3375981) 3375981..3376607 + 627 WP_001295292.1 glutathione S-transferase GstB -
LWS57_RS16480 (3376604) 3376604..3377719 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
LWS57_RS16485 (3377830) 3377830..3378213 - 384 WP_000497137.1 biofilm formation regulator BssR -
LWS57_RS16490 (3378426) 3378426..3379751 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
LWS57_RS16495 (3379977) 3379977..3380363 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LWS57_RS16500 (3380353) 3380353..3380682 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
LWS57_RS16505 (3380752) 3380752..3382080 - 1329 WP_001550887.1 GGDEF domain-containing protein -
LWS57_RS16510 (3382088) 3382088..3384436 - 2349 WP_001550886.1 EAL domain-containing protein -
LWS57_RS16515 (3384614) 3384614..3385525 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T294845 WP_000539521.1 NZ_OU701449:3379977-3380363 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT294845 WP_001280945.1 NZ_OU701449:3380353-3380682 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References