Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2732531..2733169 Replicon chromosome
Accession NZ_OU701449
Organism Escherichia coli isolate CNR85I8

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag LWS57_RS13300 Protein ID WP_000813795.1
Coordinates 2732993..2733169 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LWS57_RS13295 Protein ID WP_076797675.1
Coordinates 2732531..2732947 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS57_RS13275 (2727683) 2727683..2728624 - 942 WP_001251315.1 ABC transporter permease -
LWS57_RS13280 (2728625) 2728625..2729638 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
LWS57_RS13285 (2729656) 2729656..2730801 - 1146 WP_001551094.1 ABC transporter substrate-binding protein -
LWS57_RS13290 (2731046) 2731046..2732452 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
LWS57_RS13295 (2732531) 2732531..2732947 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LWS57_RS13300 (2732993) 2732993..2733169 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LWS57_RS13305 (2733391) 2733391..2733621 + 231 WP_023910283.1 YncJ family protein -
LWS57_RS13310 (2733713) 2733713..2735674 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LWS57_RS13315 (2735747) 2735747..2736283 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
LWS57_RS13320 (2736375) 2736375..2737547 + 1173 WP_001551088.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T294843 WP_000813795.1 NZ_OU701449:c2733169-2732993 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT294843 WP_076797675.1 NZ_OU701449:c2732947-2732531 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References