Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2627817..2629405 Replicon chromosome
Accession NZ_OU701449
Organism Escherichia coli isolate CNR85I8

Toxin (Protein)


Gene name hipA Uniprot ID A0A829LC11
Locus tag LWS57_RS12855 Protein ID WP_001551128.1
Coordinates 2628083..2629405 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LWS57_RS12850 Protein ID WP_001296726.1
Coordinates 2627817..2628083 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS57_RS12850 (2627817) 2627817..2628083 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LWS57_RS12855 (2628083) 2628083..2629405 + 1323 WP_001551128.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
LWS57_RS12860 (2629605) 2629605..2630957 - 1353 WP_001551127.1 SIR2 family protein -
LWS57_RS12865 (2631172) 2631172..2632204 - 1033 Protein_2532 ISNCY family transposase -
LWS57_RS12870 (2632571) 2632571..2633470 - 900 WP_001551125.1 LysR family transcriptional regulator -
LWS57_RS12875 (2633609) 2633609..2633917 + 309 WP_001221046.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2631172..2631990 818


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49270.88 Da        Isoelectric Point: 8.2472

>T294842 WP_001551128.1 NZ_OU701449:2628083-2629405 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGVNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT294842 WP_001296726.1 NZ_OU701449:2627817-2628083 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829LC11

Antitoxin

Source ID Structure

References