Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 977837..978491 Replicon chromosome
Accession NZ_OU701449
Organism Escherichia coli isolate CNR85I8

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag LWS57_RS04740 Protein ID WP_000244781.1
Coordinates 978084..978491 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag LWS57_RS04735 Protein ID WP_001564007.1
Coordinates 977837..978103 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS57_RS04715 (973925) 973925..975358 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
LWS57_RS04720 (975403) 975403..975714 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
LWS57_RS04725 (975878) 975878..976537 + 660 WP_000250274.1 hemolysin III family protein -
LWS57_RS04730 (976614) 976614..977594 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
LWS57_RS04735 (977837) 977837..978103 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
LWS57_RS04740 (978084) 978084..978491 + 408 WP_000244781.1 protein YgfX Toxin
LWS57_RS04745 (978531) 978531..979052 - 522 WP_001055874.1 flavodoxin FldB -
LWS57_RS04750 (979164) 979164..980060 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LWS57_RS04755 (980085) 980085..980795 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LWS57_RS04760 (980801) 980801..982534 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T294835 WP_000244781.1 NZ_OU701449:978084-978491 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT294835 WP_001564007.1 NZ_OU701449:977837-978103 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References