Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 161180..161792 Replicon chromosome
Accession NZ_OU701449
Organism Escherichia coli isolate CNR85I8

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag LWS57_RS00695 Protein ID WP_000833473.1
Coordinates 161180..161365 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag LWS57_RS00700 Protein ID WP_000499744.1
Coordinates 161382..161792 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS57_RS00685 (158021) 158021..159172 + 1152 WP_000741501.1 L-threonine dehydrogenase -
LWS57_RS00690 (159373) 159373..160911 + 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
LWS57_RS00695 (161180) 161180..161365 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
LWS57_RS00700 (161382) 161382..161792 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LWS57_RS00705 (161864) 161864..163828 - 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
LWS57_RS00710 (163839) 163839..165239 - 1401 WP_000204811.1 MFS transporter -
LWS57_RS00715 (165465) 165465..166280 + 816 WP_000891823.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T294831 WP_000833473.1 NZ_OU701449:161180-161365 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT294831 WP_000499744.1 NZ_OU701449:161382-161792 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References