29483

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2802620..2803272 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag CFBS_RS13205 Protein ID WP_003905869.1
Coordinates 2802847..2803272 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag CFBS_RS13200 Protein ID WP_003412749.1
Coordinates 2802620..2802841 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS13185 2800860..2801066 - 207 WP_003899347.1 hypothetical protein -
CFBS_RS13190 2801202..2801825 + 624 WP_003900858.1 TIGR00725 family protein -
CFBS_RS13195 2801815..2802567 + 753 WP_003901416.1 hypothetical protein -
CFBS_RS13200 2802620..2802841 + 222 WP_003412749.1 antitoxin Antitoxin
CFBS_RS13205 2802847..2803272 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
CFBS_RS13210 2803295..2804476 - 1182 WP_003905870.1 2-oxo acid dehydrogenase subunit E2 -
CFBS_RS13215 2804473..2805519 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
CFBS_RS13220 2805530..2806633 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
CFBS_RS13225 2806892..2807713 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
CFBS_RS13230 2807710..2808267 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T29483 WP_003905869.1 NC_021251:2802847-2803272 [Mycobacterium tuberculosis CCDC5079]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T29483 NC_021251:2802847-2803272 [Mycobacterium tuberculosis CCDC5079]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT29483 WP_003412749.1 NC_021251:2802620-2802841 [Mycobacterium tuberculosis CCDC5079]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT29483 NC_021251:2802620-2802841 [Mycobacterium tuberculosis CCDC5079]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References