Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3849778..3850364 Replicon chromosome
Accession NZ_OU659204
Organism Providencia alcalifaciens strain 2019-04-29291-1-1 isolate 2019-04-29291-1-1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LDO73_RS17600 Protein ID WP_224059585.1
Coordinates 3850062..3850364 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LDO73_RS17595 Protein ID WP_224059584.1
Coordinates 3849778..3850065 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO73_RS17570 (NVI2019_GHJFPKLH_03522) 3844838..3845815 - 978 WP_224059580.1 6-phosphofructokinase -
LDO73_RS17575 (NVI2019_GHJFPKLH_03523) 3846214..3847158 - 945 WP_154603265.1 phosphatidate cytidylyltransferase -
LDO73_RS17580 (NVI2019_GHJFPKLH_03524) 3847155..3847796 - 642 WP_224059581.1 lysophospholipid acyltransferase family protein -
LDO73_RS17585 (NVI2019_GHJFPKLH_03525) 3848034..3848789 - 756 WP_224059582.1 M48 family metallopeptidase -
LDO73_RS17590 (NVI2019_GHJFPKLH_03526) 3849043..3849624 - 582 WP_224059583.1 HutD family protein -
LDO73_RS17595 (NVI2019_GHJFPKLH_03527) 3849778..3850065 - 288 WP_224059584.1 putative addiction module antidote protein Antitoxin
LDO73_RS17600 (NVI2019_GHJFPKLH_03528) 3850062..3850364 - 303 WP_224059585.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO73_RS17605 (NVI2019_GHJFPKLH_03529) 3850611..3851171 - 561 WP_224059586.1 Spy/CpxP family protein refolding chaperone -
LDO73_RS17610 (NVI2019_GHJFPKLH_03530) 3851323..3852021 + 699 WP_006660535.1 envelope stress response regulator transcription factor CpxR -
LDO73_RS17615 (NVI2019_GHJFPKLH_03531) 3852018..3853388 + 1371 WP_036950809.1 envelope stress sensor histidine kinase CpxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11587.41 Da        Isoelectric Point: 10.1293

>T294829 WP_224059585.1 NZ_OU659204:c3850364-3850062 [Providencia alcalifaciens]
MLTVLTTDIFNRWMHDLKDIRAKTKIQVRIRRLKQGNFGDVEPIGDGFSELKIHEGKGYRVYLRKIDNTIVLLISGGDKS
TQQKDIDKAKQIFREIEGDL

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10547.18 Da        Isoelectric Point: 5.1489

>AT294829 WP_224059584.1 NZ_OU659204:c3850065-3849778 [Providencia alcalifaciens]
MSIKIKEYDIAEHLTNEEEIQLYLNEILEEGDTALILAALGDIARARNMTQLAKEVGMSREGLYKALSGEGNPAFTTILK
IVHSLGLKLQFKSAR

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References