Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1449809..1450603 Replicon chromosome
Accession NZ_OU659204
Organism Providencia alcalifaciens strain 2019-04-29291-1-1 isolate 2019-04-29291-1-1

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag LDO73_RS06390 Protein ID WP_224061143.1
Coordinates 1449809..1450309 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag LDO73_RS06395 Protein ID WP_224060684.1
Coordinates 1450331..1450603 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO73_RS06360 (NVI2019_GHJFPKLH_01275) 1446000..1446836 + 837 WP_224060679.1 CheR family methyltransferase -
LDO73_RS06365 (NVI2019_GHJFPKLH_01276) 1446836..1447903 + 1068 WP_224060680.1 chemotaxis response regulator protein-glutamate methylesterase -
LDO73_RS06370 (NVI2019_GHJFPKLH_01277) 1447946..1448338 + 393 WP_224060681.1 chemotaxis response regulator CheY -
LDO73_RS06375 (NVI2019_GHJFPKLH_01278) 1448363..1449007 + 645 WP_224060682.1 protein phosphatase CheZ -
LDO73_RS06380 (NVI2019_GHJFPKLH_01279) 1449121..1449429 - 309 WP_224060683.1 CcdB family protein -
LDO73_RS06385 (NVI2019_GHJFPKLH_01280) 1449429..1449665 - 237 WP_154604175.1 type II toxin-antitoxin system CcdA family antitoxin -
LDO73_RS06390 (NVI2019_GHJFPKLH_01281) 1449809..1450309 - 501 WP_224061143.1 GNAT family N-acetyltransferase Toxin
LDO73_RS06395 (NVI2019_GHJFPKLH_01282) 1450331..1450603 - 273 WP_224060684.1 DUF1778 domain-containing protein Antitoxin
LDO73_RS06400 (NVI2019_GHJFPKLH_01283) 1451018..1451365 - 348 WP_006657500.1 HNH nuclease YajD -
LDO73_RS06405 (NVI2019_GHJFPKLH_01284) 1451650..1452801 + 1152 WP_224060685.1 flagellar biosynthesis protein FlhB -
LDO73_RS06410 (NVI2019_GHJFPKLH_01285) 1452794..1454890 + 2097 WP_224060686.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(40-142)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19036.83 Da        Isoelectric Point: 7.4130

>T294825 WP_224061143.1 NZ_OU659204:c1450309-1449809 [Providencia alcalifaciens]
MYSEEIDYDLTHFDCGEPYMNTFLTEHLKRQHKNQVLRGYMLLTKEEKPRVMGYYTLSGSSFEKRTLPSRQRQIMVPSES
APSVTLGRLAIDKSIQRQGYGELLVVHAMRVVYQASHAVGIYGLFVEALNDKAKQFYLGLGFIQLTGENAASFFYPTKSI
ETLFDM

Download         Length: 501 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.69 Da        Isoelectric Point: 6.4694

>AT294825 WP_224060684.1 NZ_OU659204:c1450603-1450331 [Providencia alcalifaciens]
MLAPKTKRIDLRLNEEDKNLIEEAAAITNLSISQFMINIASERASEIVNHHRRLILNENSWDLVQNAINNPPAVNNRLKQ
AAKRLQDTEE

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References