Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1449121..1449665 Replicon chromosome
Accession NZ_OU659204
Organism Providencia alcalifaciens strain 2019-04-29291-1-1 isolate 2019-04-29291-1-1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LDO73_RS06380 Protein ID WP_224060683.1
Coordinates 1449121..1449429 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LDO73_RS06385 Protein ID WP_154604175.1
Coordinates 1449429..1449665 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO73_RS06355 (NVI2019_GHJFPKLH_01274) 1444276..1445841 + 1566 WP_224060678.1 methyl-accepting chemotaxis protein -
LDO73_RS06360 (NVI2019_GHJFPKLH_01275) 1446000..1446836 + 837 WP_224060679.1 CheR family methyltransferase -
LDO73_RS06365 (NVI2019_GHJFPKLH_01276) 1446836..1447903 + 1068 WP_224060680.1 chemotaxis response regulator protein-glutamate methylesterase -
LDO73_RS06370 (NVI2019_GHJFPKLH_01277) 1447946..1448338 + 393 WP_224060681.1 chemotaxis response regulator CheY -
LDO73_RS06375 (NVI2019_GHJFPKLH_01278) 1448363..1449007 + 645 WP_224060682.1 protein phosphatase CheZ -
LDO73_RS06380 (NVI2019_GHJFPKLH_01279) 1449121..1449429 - 309 WP_224060683.1 CcdB family protein Toxin
LDO73_RS06385 (NVI2019_GHJFPKLH_01280) 1449429..1449665 - 237 WP_154604175.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LDO73_RS06390 (NVI2019_GHJFPKLH_01281) 1449809..1450309 - 501 WP_224061143.1 GNAT family N-acetyltransferase -
LDO73_RS06395 (NVI2019_GHJFPKLH_01282) 1450331..1450603 - 273 WP_224060684.1 DUF1778 domain-containing protein -
LDO73_RS06400 (NVI2019_GHJFPKLH_01283) 1451018..1451365 - 348 WP_006657500.1 HNH nuclease YajD -
LDO73_RS06405 (NVI2019_GHJFPKLH_01284) 1451650..1452801 + 1152 WP_224060685.1 flagellar biosynthesis protein FlhB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-76)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11737.79 Da        Isoelectric Point: 5.5703

>T294823 WP_224060683.1 NZ_OU659204:c1449429-1449121 [Providencia alcalifaciens]
MQYCVYQAKKEPTNYPYLLDVQSDIIDDLTTRLVIPLFDTRHLQAALPIRLNPMIDIEGQPFVLMTHLMSAISKSMLGKE
VICIEHQRDKIKSAIDLLFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8955.25 Da        Isoelectric Point: 5.1249

>AT294823 WP_154604175.1 NZ_OU659204:c1449665-1449429 [Providencia alcalifaciens]
MTVANKMKKTVSVTVSPELYEQARKANLNFSLVLSNALLAELKKLEALKWKADNQDGFQELNRISEEYGIFSEEYKEL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References