Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 834060..834704 Replicon chromosome
Accession NZ_OU659204
Organism Providencia alcalifaciens strain 2019-04-29291-1-1 isolate 2019-04-29291-1-1

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag LDO73_RS03625 Protein ID WP_004905417.1
Coordinates 834060..834263 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LDO73_RS03630 Protein ID WP_224060232.1
Coordinates 834336..834704 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO73_RS03605 (NVI2019_GHJFPKLH_00721) 829911..831689 + 1779 WP_224060229.1 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -
LDO73_RS03610 (NVI2019_GHJFPKLH_00722) 831847..832713 - 867 WP_224060230.1 acyl-CoA thioesterase II -
LDO73_RS03615 (NVI2019_GHJFPKLH_00723) 832952..833410 + 459 WP_224060231.1 YbaY family lipoprotein -
LDO73_RS03625 (NVI2019_GHJFPKLH_00724) 834060..834263 - 204 WP_004905417.1 HHA domain-containing protein Toxin
LDO73_RS03630 (NVI2019_GHJFPKLH_00725) 834336..834704 - 369 WP_224060232.1 Hha toxicity modulator TomB Antitoxin
LDO73_RS03635 (NVI2019_GHJFPKLH_00726) 835232..836611 - 1380 WP_224060233.1 murein transglycosylase D -
LDO73_RS03640 (NVI2019_GHJFPKLH_00727) 836694..837446 - 753 WP_224060234.1 hydroxyacylglutathione hydrolase -
LDO73_RS03645 (NVI2019_GHJFPKLH_00728) 837481..838206 + 726 WP_224060235.1 methyltransferase domain-containing protein -
LDO73_RS03650 (NVI2019_GHJFPKLH_00729) 838219..838689 - 471 WP_224060236.1 ribonuclease HI -
LDO73_RS03655 (NVI2019_GHJFPKLH_00730) 838744..839505 + 762 WP_224060237.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T294822 WP_004905417.1 NZ_OU659204:c834263-834060 [Providencia alcalifaciens]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14129.01 Da        Isoelectric Point: 4.4687

>AT294822 WP_224060232.1 NZ_OU659204:c834704-834336 [Providencia alcalifaciens]
MDEYSPKKHDIAELKYLCNSLNRDAISSLQKTNTHWINDLSSAQSISLNELVEHIAAFVWRFKIKYPKENLVISLVEEYL
DETYNLFGSPVITFNEIIDWESMNQNLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure

References