294818

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HTH_XRE(antitoxin)
Location 44970..45391 Replicon plasmid 3
Accession NZ_OU659164
Organism Providencia alcalifaciens strain 2019-04-29292-1-3 isolate 2019-04-29292-1-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LDO74_RS20315 Protein ID WP_036974639.1
Coordinates 44970..45248 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO74_RS21285 Protein ID WP_282563865.1
Coordinates 45248..45391 (+) Length 48 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO74_RS20285 (NVI2019_OGMBKCAO_04080) 40508..41143 + 636 WP_282563867.1 type-F conjugative transfer system pilin assembly protein TrbC -
LDO74_RS21280 41809..42798 + 990 Protein_39 conjugal transfer protein TraN -
LDO74_RS20295 (NVI2019_OGMBKCAO_04082) 42984..43739 + 756 WP_282490794.1 type-F conjugative transfer system pilin assembly protein TraF -
LDO74_RS20300 (NVI2019_OGMBKCAO_04083) 43760..44050 + 291 WP_224051145.1 hypothetical protein -
LDO74_RS20305 (NVI2019_OGMBKCAO_04084) 44056..44586 + 531 WP_224051144.1 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB -
LDO74_RS20310 (NVI2019_OGMBKCAO_04085) 44689..44979 + 291 WP_282563866.1 ribbon-helix-helix domain-containing protein -
LDO74_RS20315 (NVI2019_OGMBKCAO_04086) 44970..45248 + 279 WP_036974639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO74_RS21285 (NVI2019_OGMBKCAO_04087) 45248..45391 + 144 WP_282563865.1 hypothetical protein Antitoxin
LDO74_RS20325 (NVI2019_OGMBKCAO_04088) 45797..47191 + 1395 WP_282563883.1 conjugal transfer pilus assembly protein TraH -
LDO74_RS20330 (NVI2019_OGMBKCAO_04089) 47204..50098 + 2895 WP_282563864.1 conjugal transfer mating-pair stabilization protein TraG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91748 91748


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10909.82 Da        Isoelectric Point: 9.8960

>T294818 WP_036974639.1 NZ_OU659164:44970-45248 [Providencia alcalifaciens]
MELKWTSKALSDLSRVYDFLALSNSVAAARVVQTLTKAPMLLLIKNPRMGEQLFQFMPHEVRRIVVVNYEIRYELIDSTI
YILRIWHTREDR

Download         Length: 279 bp

Antitoxin


Download         Length: 48 a.a.        Molecular weight: 5122.95 Da        Isoelectric Point: 8.2941

>AT294818 WP_282563865.1 NZ_OU659164:45248-45391 [Providencia alcalifaciens]
MRQFKVSHLGEIIARDLADMGISGRRFALNIDVTPATAGNSNCCCIR

Download         Length: 144 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References