Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 19437..19959 Replicon plasmid 3
Accession NZ_OU659164
Organism Providencia alcalifaciens strain 2019-04-29292-1-3 isolate 2019-04-29292-1-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LDO74_RS20150 Protein ID WP_036979529.1
Coordinates 19678..19959 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LDO74_RS20145 Protein ID WP_036974972.1
Coordinates 19437..19688 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO74_RS20120 (NVI2019_OGMBKCAO_04045) 14792..15040 - 249 Protein_6 transposase -
LDO74_RS20125 (NVI2019_OGMBKCAO_04046) 15992..16297 + 306 WP_224051165.1 ProQ/FINO family protein -
LDO74_RS20130 16432..17156 + 725 Protein_8 substrate-binding domain-containing protein -
LDO74_RS20135 (NVI2019_OGMBKCAO_04049) 17328..18287 + 960 WP_224051164.1 Rpn family recombination-promoting nuclease/putative transposase -
LDO74_RS20140 (NVI2019_OGMBKCAO_04050) 18697..19278 + 582 WP_036982181.1 recombinase family protein -
LDO74_RS20145 (NVI2019_OGMBKCAO_04051) 19437..19688 + 252 WP_036974972.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LDO74_RS20150 (NVI2019_OGMBKCAO_04052) 19678..19959 + 282 WP_036979529.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO74_RS20155 (NVI2019_OGMBKCAO_04053) 20643..21266 + 624 WP_036974649.1 ParA family partition ATPase -
LDO74_RS20160 (NVI2019_OGMBKCAO_04054) 21268..21522 + 255 WP_224051163.1 plasmid partition protein ParG -
LDO74_RS20165 (NVI2019_OGMBKCAO_04055) 21631..21975 - 345 WP_051420194.1 plasmid partitioning/stability family protein -
LDO74_RS20170 (NVI2019_OGMBKCAO_04056) 21975..22943 - 969 WP_036974617.1 plasmid segregation protein ParM -
LDO74_RS20175 (NVI2019_OGMBKCAO_04057) 23441..23650 + 210 WP_036979533.1 hypothetical protein -
LDO74_RS20180 (NVI2019_OGMBKCAO_04058) 24488..24739 + 252 WP_036954407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91748 91748


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.01 Da        Isoelectric Point: 10.6508

>T294816 WP_036979529.1 NZ_OU659164:19678-19959 [Providencia alcalifaciens]
MTYKLEFDRRALKEWQKLAPPIRNQFKKKLLERIENPCVPSAKLSGKNNRYKIKLRSLGYRLIYEVIDEKIILLVIAVGK
REGNTVYFSSNER

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9116.31 Da        Isoelectric Point: 3.7550

>AT294816 WP_036974972.1 NZ_OU659164:19437-19688 [Providencia alcalifaciens]
MTYQILSDTAASITDLKKNPMGTIAGGEGNPVAILNRNEPAFYCVPPELFAWFMELAEDAELNKIADERLESLDVVSVNI
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References