Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 65976..66535 Replicon plasmid 3
Accession NZ_OU659127
Organism Providencia alcalifaciens strain 2019-04-29034-1-3 isolate 2019-04-29034-1-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LDO30_RS20310 Protein ID WP_036974639.1
Coordinates 65976..66254 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LDO30_RS20315 Protein ID WP_282563866.1
Coordinates 66245..66535 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO30_RS20295 (NVI2019_ANGEOOBF_04081) 61126..64020 - 2895 WP_282563864.1 conjugal transfer mating-pair stabilization protein TraG -
LDO30_RS20300 (NVI2019_ANGEOOBF_04082) 64033..65427 - 1395 WP_282563883.1 conjugal transfer pilus assembly protein TraH -
LDO30_RS21260 (NVI2019_ANGEOOBF_04083) 65833..65976 - 144 WP_282563865.1 hypothetical protein -
LDO30_RS20310 (NVI2019_ANGEOOBF_04084) 65976..66254 - 279 WP_036974639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO30_RS20315 (NVI2019_ANGEOOBF_04085) 66245..66535 - 291 WP_282563866.1 ribbon-helix-helix domain-containing protein Antitoxin
LDO30_RS20320 (NVI2019_ANGEOOBF_04086) 66638..67168 - 531 WP_224051144.1 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB -
LDO30_RS20325 (NVI2019_ANGEOOBF_04087) 67174..67464 - 291 WP_224051145.1 hypothetical protein -
LDO30_RS20330 (NVI2019_ANGEOOBF_04088) 67485..68240 - 756 WP_282490794.1 type-F conjugative transfer system pilin assembly protein TraF -
LDO30_RS21265 68474..69415 - 942 Protein_53 conjugal transfer protein TraN -
LDO30_RS20340 (NVI2019_ANGEOOBF_04090) 70081..70716 - 636 WP_282563867.1 type-F conjugative transfer system pilin assembly protein TrbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91740 91740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-50)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10909.82 Da        Isoelectric Point: 9.8960

>T294800 WP_036974639.1 NZ_OU659127:c66254-65976 [Providencia alcalifaciens]
MELKWTSKALSDLSRVYDFLALSNSVAAARVVQTLTKAPMLLLIKNPRMGEQLFQFMPHEVRRIVVVNYEIRYELIDSTI
YILRIWHTREDR

Download         Length: 279 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10831.31 Da        Isoelectric Point: 4.8096

>AT294800 WP_282563866.1 NZ_OU659127:c66535-66245 [Providencia alcalifaciens]
MKNSSVQNKTKVLTAHVPLTMADKIDEIAERLERSRGWVMKQALSTWIAQEEMRDTLTREALLDVESGQVIDNQSVQDWA
ASLNTELPLPVPRWN

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References