Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 122801..123323 Replicon plasmid 2
Accession NZ_OU659126
Organism Providencia alcalifaciens strain 2019-04-29034-1-3 isolate 2019-04-29034-1-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LDO30_RS19785 Protein ID WP_036974970.1
Coordinates 123042..123323 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LDO30_RS19780 Protein ID WP_036974972.1
Coordinates 122801..123052 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO30_RS19745 (NVI2019_ANGEOOBF_03967) 117812..118090 - 279 WP_036979198.1 ribbon-helix-helix protein, CopG family -
LDO30_RS19750 (NVI2019_ANGEOOBF_03968) 118042..118728 - 687 WP_282563839.1 AAA family ATPase -
LDO30_RS19755 (NVI2019_ANGEOOBF_03970) 119331..120542 + 1212 Protein_92 IS3 family transposase -
LDO30_RS19760 (NVI2019_ANGEOOBF_03971) 120588..120935 + 348 WP_051420173.1 ParB/Srx family N-terminal domain-containing protein -
LDO30_RS21075 120956..121078 + 123 WP_263422648.1 hypothetical protein -
LDO30_RS19765 (NVI2019_ANGEOOBF_03972) 121433..121729 + 297 WP_282563840.1 hypothetical protein -
LDO30_RS19770 (NVI2019_ANGEOOBF_03973) 121672..122205 + 534 WP_282563841.1 type-F conjugative transfer system pilin assembly protein TraF -
LDO30_RS19775 122205..122629 + 425 Protein_97 recombinase family protein -
LDO30_RS19780 (NVI2019_ANGEOOBF_03975) 122801..123052 + 252 WP_036974972.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LDO30_RS19785 (NVI2019_ANGEOOBF_03976) 123042..123323 + 282 WP_036974970.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO30_RS19790 123552..123854 + 303 Protein_100 recombinase family protein -
LDO30_RS19800 (NVI2019_ANGEOOBF_03978) 124099..124368 + 270 WP_036979554.1 plasmid partitioning/stability family protein -
LDO30_RS19805 (NVI2019_ANGEOOBF_03979) 124563..124841 + 279 WP_230087585.1 S24 family peptidase -
LDO30_RS19810 (NVI2019_ANGEOOBF_03980) 124954..126222 + 1269 WP_036979530.1 translesion error-prone DNA polymerase V subunit UmuC -
LDO30_RS19815 (NVI2019_ANGEOOBF_03981) 126429..126755 + 327 WP_036979532.1 type II toxin-antitoxin system RelE/ParE family toxin -
LDO30_RS19820 (NVI2019_ANGEOOBF_03982) 126742..127014 + 273 WP_036979555.1 helix-turn-helix transcriptional regulator -
LDO30_RS19825 (NVI2019_ANGEOOBF_03983) 127109..127318 + 210 WP_036979533.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cdtA / cdtB / cdtB / cdtC / invA / invC/sctN / spaP / spaQ / spaS / sicA / prgI / prgK / exeG / stcE / yopJ/yopP 1..171426 171426
- inside IScluster/Tn - - 119368..123875 4507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.01 Da        Isoelectric Point: 10.6508

>T294796 WP_036974970.1 NZ_OU659126:123042-123323 [Providencia alcalifaciens]
MTYKLEFDRRALKEWQKLAPPIRNQFKKKLLERLENPCVPSAKLSGKNNRYKIKLRSLGYRLIYEVIDEKIILLVIAVGK
REGNTVYFSSNER

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9116.31 Da        Isoelectric Point: 3.7550

>AT294796 WP_036974972.1 NZ_OU659126:122801-123052 [Providencia alcalifaciens]
MTYQILSDTAASITDLKKNPMGTIAGGEGNPVAILNRNEPAFYCVPPELFAWFMELAEDAELNKIADERLESLDVVSVNI
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References