Detailed information of TA system TA294791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 36081..37809
• Replicon: plasmid 3
• Accession: NZ_OU659122
• Organism: Providencia alcalifaciens strain 2019-04-28369-1-2 isolate 2019-04-28369-1-2

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LDO76_RS20190
• Protein ID: WP_224051181.1
• Coordinates: 36081..37025 (-)
• Length: 315 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: LDO76_RS20195
• Protein ID: WP_224051182.1
• Coordinates: 37039..37809 (-)
• Length: 257 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO76_RS21100	34302..34424	-	123	WP_263422652.1	hypothetical protein	-
LDO76_RS20185 (NVI2019_PLFLNFOB_04058)	35165..35452	+	288	WP_224051180.1	hypothetical protein	-
LDO76_RS20190 (NVI2019_PLFLNFOB_04060)	36081..37025	-	945	WP_224051181.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LDO76_RS20195 (NVI2019_PLFLNFOB_04061)	37039..37809	-	771	WP_224051182.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LDO76_RS20200	38099..38608	-	510	Protein_26	Tn3 family transposase	-
LDO76_RS20205	38576..38686	+	111	Protein_27	resolvase	-
LDO76_RS20210 (NVI2019_PLFLNFOB_04062)	38814..40760	-	1947	WP_282563880.1	hypothetical protein	-
LDO76_RS20215 (NVI2019_PLFLNFOB_04063)	40733..41419	-	687	WP_282564774.1	hypothetical protein	-
LDO76_RS20225 (NVI2019_PLFLNFOB_04065)	42011..42805	-	795	WP_224051186.1	DUF1460 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..91756	91756

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (20-277)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-97)

Sequences

Toxin

Protein

• Length: 315 a.a.
• Molecular weight: 35625.02 Da
• Isoelectric Point: 4.9792

>T294791 WP_224051181.1 NZ_OU659122:c37025-36081 [Providencia alcalifaciens]
MDRDSPYYKQVSLLIKILPVIATEPTFALKGGTAINLFVRNFPRLSVDIDLAYLPLESRNDALVNVKASLLRITDLINTQ
VDTRAVLQDHKVDELRIIVNSPGGTIKVEVSPVARGALHQPSILSVQPSVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLAEEGISRDIFVGFLTYVLSHPRPINEVMDPNWKPLDEIFQTEFDGMTLVNIELEDLIEVRSAMMTALQA
HFTEKDRVFLLSFKQGNPDWALFDYPSAEGLPAIRWKLQNIAQLAKNRDKYTEQLSKLEVVLDRWLHSADKQRL

Nucleotide

• Length: 945 bp

Antitoxin

Protein

• Length: 257 a.a.
• Molecular weight: 29452.77 Da
• Isoelectric Point: 9.6991

>AT294791 WP_224051182.1 NZ_OU659122:c37809-37039 [Providencia alcalifaciens]
MSSKINWLVTHTYPGSIVLQQWLTKNGISYSLAQKYTQSGWLKKLSSGVYFRPDGKDGTKPDWVDALQAINIQQCLPVHL
AGLSSLNHQGLSHYLQLRKEQLWIGIKSKQSLPKWFREFPNQDWFYCGNSKLQIDPDMDLKFITVKGKELLVSRSELAAY
EVVDAIGKQISFEHVAELFQGLVNLSPKRVQSLLERSHAIQTNRIFLFLSHHCDHQWGEYLNEKNIELGSGKRQVVNKGR
LDERYQITVPESLKTK

Nucleotide

• Length: 771 bp