Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3161380..3162024 Replicon chromosome
Accession NZ_OU659120
Organism Providencia alcalifaciens strain 2019-04-28369-1-2 isolate 2019-04-28369-1-2

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag LDO76_RS15135 Protein ID WP_004905417.1
Coordinates 3161821..3162024 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LDO76_RS15130 Protein ID WP_006662760.1
Coordinates 3161380..3161748 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO76_RS15105 (NVI2019_PLFLNFOB_03032) 3156579..3157340 - 762 WP_006662757.1 DNA polymerase III subunit epsilon -
LDO76_RS15110 (NVI2019_PLFLNFOB_03033) 3157395..3157865 + 471 WP_006657236.1 ribonuclease HI -
LDO76_RS15115 (NVI2019_PLFLNFOB_03034) 3157878..3158603 - 726 WP_006657235.1 methyltransferase domain-containing protein -
LDO76_RS15120 (NVI2019_PLFLNFOB_03035) 3158640..3159392 + 753 WP_224050830.1 hydroxyacylglutathione hydrolase -
LDO76_RS15125 (NVI2019_PLFLNFOB_03036) 3159475..3160854 + 1380 WP_036961894.1 murein transglycosylase D -
LDO76_RS15130 (NVI2019_PLFLNFOB_03037) 3161380..3161748 + 369 WP_006662760.1 Hha toxicity modulator TomB Antitoxin
LDO76_RS15135 (NVI2019_PLFLNFOB_03038) 3161821..3162024 + 204 WP_004905417.1 HHA domain-containing protein Toxin
LDO76_RS21205 3162639..3162929 - 291 WP_282563797.1 YbaY family lipoprotein -
LDO76_RS15150 (NVI2019_PLFLNFOB_03040) 3163336..3164202 + 867 WP_006662762.1 acyl-CoA thioesterase II -
LDO76_RS15155 (NVI2019_PLFLNFOB_03041) 3164349..3166130 - 1782 WP_036967305.1 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T294788 WP_004905417.1 NZ_OU659120:3161821-3162024 [Providencia alcalifaciens]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14087.96 Da        Isoelectric Point: 4.4687

>AT294788 WP_006662760.1 NZ_OU659120:3161380-3161748 [Providencia alcalifaciens]
MDEYSPKKHDIAELKYLCNSLNRDAISSLQKTNTHWINDLSSAQSISLNELVEHIAAFVWRFKIKYPKENLVISLVEEYL
DETYNLFGSPVVTFSEIIDWESMNQNLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure

References