Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 856757..857401 Replicon chromosome
Accession NZ_OU659118
Organism Providencia alcalifaciens strain 2019-01-3283-1-1 isolate 2019-01-3283-1-1

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag LDO75_RS03870 Protein ID WP_004905417.1
Coordinates 856757..856960 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LDO75_RS03875 Protein ID WP_006662760.1
Coordinates 857033..857401 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO75_RS03850 (NVI2019_PEGOAJLN_00779) 852651..854432 + 1782 WP_224063740.1 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -
LDO75_RS03855 (NVI2019_PEGOAJLN_00780) 854579..855445 - 867 WP_006662762.1 acyl-CoA thioesterase II -
LDO75_RS19280 855852..856142 + 291 WP_282558955.1 YbaY family lipoprotein -
LDO75_RS03870 (NVI2019_PEGOAJLN_00782) 856757..856960 - 204 WP_004905417.1 HHA domain-containing protein Toxin
LDO75_RS03875 (NVI2019_PEGOAJLN_00783) 857033..857401 - 369 WP_006662760.1 Hha toxicity modulator TomB Antitoxin
LDO75_RS03880 (NVI2019_PEGOAJLN_00784) 857927..859306 - 1380 WP_036974891.1 murein transglycosylase D -
LDO75_RS03885 (NVI2019_PEGOAJLN_00785) 859389..860141 - 753 WP_006657234.1 hydroxyacylglutathione hydrolase -
LDO75_RS03890 (NVI2019_PEGOAJLN_00786) 860178..860903 + 726 WP_036974888.1 methyltransferase domain-containing protein -
LDO75_RS03895 (NVI2019_PEGOAJLN_00787) 860916..861386 - 471 WP_006657236.1 ribonuclease HI -
LDO75_RS03900 (NVI2019_PEGOAJLN_00788) 861441..862202 + 762 WP_006662757.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T294782 WP_004905417.1 NZ_OU659118:c856960-856757 [Providencia alcalifaciens]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14087.96 Da        Isoelectric Point: 4.4687

>AT294782 WP_006662760.1 NZ_OU659118:c857401-857033 [Providencia alcalifaciens]
MDEYSPKKHDIAELKYLCNSLNRDAISSLQKTNTHWINDLSSAQSISLNELVEHIAAFVWRFKIKYPKENLVISLVEEYL
DETYNLFGSPVVTFSEIIDWESMNQNLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure

References