29478

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2250234..2250860 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag CFBS_RS10565 Protein ID WP_003410075.1
Coordinates 2250462..2250860 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag CFBS_RS10560 Protein ID WP_003911750.1
Coordinates 2250234..2250461 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS10550 2248273..2248617 - 345 WP_003410065.1 ferredoxin family protein -
CFBS_RS10555 2248806..2249975 - 1170 WP_003899126.1 ATP-binding protein -
CFBS_RS10560 2250234..2250461 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CFBS_RS10565 2250462..2250860 + 399 WP_003410075.1 PIN domain nuclease Toxin
CFBS_RS10570 2251043..2251474 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
CFBS_RS10575 2251575..2252009 + 435 WP_003914358.1 DUF1398 domain-containing protein -
CFBS_RS21415 2252446..2252625 - 180 Protein_2068 hypothetical protein -
CFBS_RS10580 2252686..2253333 + 648 WP_071854215.1 transposase -
CFBS_RS10585 2253287..2253877 + 591 WP_003899131.1 IS110 family transposase -
CFBS_RS10590 2254005..2255261 - 1257 WP_003902247.1 HNH endonuclease -
CFBS_RS10595 2255615..2255815 + 201 Protein_2072 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T29478 WP_003410075.1 NC_021251:2250462-2250860 [Mycobacterium tuberculosis CCDC5079]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T29478 NC_021251:2250462-2250860 [Mycobacterium tuberculosis CCDC5079]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT29478 WP_003911750.1 NC_021251:2250234-2250461 [Mycobacterium tuberculosis CCDC5079]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT29478 NC_021251:2250234-2250461 [Mycobacterium tuberculosis CCDC5079]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References