Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4922349..4922865 Replicon chromosome
Accession NZ_OU453210
Organism Klebsiella pneumoniae isolate Klebsiella pneumoniae

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag K3775_RS24085 Protein ID WP_009486548.1
Coordinates 4922349..4922633 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K3775_RS24090 Protein ID WP_002886901.1
Coordinates 4922623..4922865 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3775_RS24060 (4917766) 4917766..4918074 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
K3775_RS24065 (4918159) 4918159..4918332 + 174 WP_032433782.1 hypothetical protein -
K3775_RS24070 (4918335) 4918335..4919078 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K3775_RS24075 (4919435) 4919435..4921573 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K3775_RS24080 (4921881) 4921881..4922345 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K3775_RS24085 (4922349) 4922349..4922633 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K3775_RS24090 (4922623) 4922623..4922865 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K3775_RS24095 (4922943) 4922943..4924853 - 1911 WP_009486549.1 PRD domain-containing protein -
K3775_RS24100 (4924876) 4924876..4926030 - 1155 WP_002886900.1 lactonase family protein -
K3775_RS24105 (4926097) 4926097..4926837 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T294769 WP_009486548.1 NZ_OU453210:c4922633-4922349 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT294769 WP_002886901.1 NZ_OU453210:c4922865-4922623 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References