Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2720841..2722429 Replicon chromosome
Accession NZ_OU453210
Organism Klebsiella pneumoniae isolate Klebsiella pneumoniae

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag K3775_RS13535 Protein ID WP_002904792.1
Coordinates 2720841..2722163 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag K3775_RS13540 Protein ID WP_002904790.1
Coordinates 2722163..2722429 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3775_RS13520 (2715897) 2715897..2718398 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
K3775_RS13525 (2718386) 2718386..2719390 + 1005 WP_032433097.1 fimbrial protein -
K3775_RS13530 (2719532) 2719532..2720824 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
K3775_RS13535 (2720841) 2720841..2722163 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
K3775_RS13540 (2722163) 2722163..2722429 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K3775_RS13545 (2722815) 2722815..2723141 - 327 WP_002904788.1 hydroxyisourate hydrolase -
K3775_RS13550 (2723138) 2723138..2723638 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
K3775_RS13555 (2723616) 2723616..2724995 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
K3775_RS13560 (2725341) 2725341..2726495 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
K3775_RS13565 (2726476) 2726476..2727399 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T294765 WP_002904792.1 NZ_OU453210:c2722163-2720841 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT294765 WP_002904790.1 NZ_OU453210:c2722429-2722163 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References