Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1523571..1524307 Replicon chromosome
Accession NZ_OU453210
Organism Klebsiella pneumoniae isolate Klebsiella pneumoniae

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag K3775_RS07630 Protein ID WP_032433360.1
Coordinates 1523825..1524307 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag K3775_RS07625 Protein ID WP_003026799.1
Coordinates 1523571..1523837 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3775_RS07600 (1519217) 1519217..1520356 + 1140 WP_032433368.1 mannitol dehydrogenase -
K3775_RS07605 (1520385) 1520385..1521047 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
K3775_RS07610 (1521031) 1521031..1522035 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
K3775_RS07615 (1522053) 1522053..1522685 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
K3775_RS07620 (1522695) 1522695..1523258 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
K3775_RS07625 (1523571) 1523571..1523837 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
K3775_RS07630 (1523825) 1523825..1524307 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
K3775_RS07635 (1524507) 1524507..1525910 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
K3775_RS07640 (1525939) 1525939..1526571 - 633 WP_001567369.1 hypothetical protein -
K3775_RS07645 (1526951) 1526951..1527550 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
K3775_RS07650 (1527763) 1527763..1528707 - 945 WP_077254249.1 fimbrial protein -
K3775_RS07655 (1528719) 1528719..1529297 - 579 WP_032432061.1 type 1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1491516..1537534 46018
- flank IS/Tn - - 1524507..1525910 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T294760 WP_032433360.1 NZ_OU453210:1523825-1524307 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT294760 WP_003026799.1 NZ_OU453210:1523571-1523837 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References