Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1506880..1507523 Replicon chromosome
Accession NZ_OU453210
Organism Klebsiella pneumoniae isolate Klebsiella pneumoniae

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag K3775_RS07535 Protein ID WP_032433387.1
Coordinates 1507107..1507523 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag K3775_RS07530 Protein ID WP_001261276.1
Coordinates 1506880..1507110 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3775_RS07515 (1501902) 1501902..1502989 + 1088 Protein_1471 transcriptional regulator -
K3775_RS07520 (1502992) 1502992..1505232 + 2241 WP_045326788.1 P-loop NTPase fold protein -
K3775_RS07525 (1505760) 1505760..1506575 - 816 WP_032433388.1 hypothetical protein -
K3775_RS07530 (1506880) 1506880..1507110 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K3775_RS07535 (1507107) 1507107..1507523 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
K3775_RS07540 (1507679) 1507679..1508659 + 981 WP_032433385.1 hypothetical protein -
K3775_RS07545 (1508854) 1508854..1510425 - 1572 WP_032433383.1 AAA family ATPase -
K3775_RS07550 (1510744) 1510744..1510992 + 249 WP_032433382.1 hypothetical protein -
K3775_RS07555 (1511051) 1511051..1511569 + 519 WP_045326794.1 hypothetical protein -
K3775_RS07560 (1511600) 1511600..1512091 + 492 WP_032433378.1 hypothetical protein -
K3775_RS07565 (1512151) 1512151..1512354 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1491516..1537534 46018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T294759 WP_032433387.1 NZ_OU453210:1507107-1507523 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT294759 WP_001261276.1 NZ_OU453210:1506880-1507110 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References