Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 851485..852142 Replicon chromosome
Accession NZ_OU453210
Organism Klebsiella pneumoniae isolate Klebsiella pneumoniae

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K3775_RS04295 Protein ID WP_002916310.1
Coordinates 851732..852142 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K3775_RS04290 Protein ID WP_002916312.1
Coordinates 851485..851751 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3775_RS04265 (846641) 846641..848074 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
K3775_RS04270 (848193) 848193..848921 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K3775_RS04275 (848971) 848971..849282 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K3775_RS04280 (849446) 849446..850105 + 660 WP_002916317.1 hemolysin III family protein -
K3775_RS04285 (850256) 850256..851239 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K3775_RS04290 (851485) 851485..851751 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K3775_RS04295 (851732) 851732..852142 + 411 WP_002916310.1 protein YgfX Toxin
K3775_RS04300 (852149) 852149..852670 - 522 WP_004144730.1 flavodoxin FldB -
K3775_RS04305 (852771) 852771..853667 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K3775_RS04310 (853690) 853690..854403 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K3775_RS04315 (854409) 854409..856142 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T294758 WP_002916310.1 NZ_OU453210:851732-852142 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT294758 WP_002916312.1 NZ_OU453210:851485-851751 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References