Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4217017..4217655 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LIX80_RS20530 Protein ID WP_000813794.1
Coordinates 4217479..4217655 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LIX80_RS20525 Protein ID WP_001270286.1
Coordinates 4217017..4217433 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS20505 (4212169) 4212169..4213110 - 942 WP_001251315.1 ABC transporter permease -
LIX80_RS20510 (4213111) 4213111..4214124 - 1014 WP_226397320.1 ABC transporter ATP-binding protein -
LIX80_RS20515 (4214142) 4214142..4215287 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
LIX80_RS20520 (4215532) 4215532..4216938 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
LIX80_RS20525 (4217017) 4217017..4217433 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LIX80_RS20530 (4217479) 4217479..4217655 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LIX80_RS20535 (4217877) 4217877..4218107 + 231 WP_000494244.1 YncJ family protein -
LIX80_RS20540 (4218199) 4218199..4220160 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LIX80_RS20545 (4220233) 4220233..4220769 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LIX80_RS20550 (4220861) 4220861..4222036 + 1176 WP_001236258.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T294746 WP_000813794.1 NZ_OU342919:c4217655-4217479 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT294746 WP_001270286.1 NZ_OU342919:c4217433-4217017 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References