294745

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4107645..4109233 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name hipA Uniprot ID F4NFZ0
Locus tag LIX80_RS19990 Protein ID WP_001125463.1
Coordinates 4107911..4109233 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LIX80_RS19985 Protein ID WP_001296726.1
Coordinates 4107645..4107911 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS19985 (4107645) 4107645..4107911 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LIX80_RS19990 (4107911) 4107911..4109233 + 1323 WP_001125463.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
LIX80_RS19995 (4109411) 4109411..4110199 - 789 WP_052907450.1 hypothetical protein -
LIX80_RS20000 (4110201) 4110201..4110485 - 285 WP_052907449.1 hypothetical protein -
LIX80_RS20005 (4110635) 4110635..4111057 - 423 WP_052907448.1 hypothetical protein -
LIX80_RS20010 (4111146) 4111146..4111328 - 183 WP_001335098.1 hypothetical protein -
LIX80_RS20015 (4111498) 4111498..4112550 + 1053 WP_000568120.1 phage/plasmid replication protein, II/X family -
LIX80_RS20020 (4112562) 4112562..4112879 + 318 WP_000073833.1 DNA-binding protein -
LIX80_RS20030 (4113083) 4113083..4113325 + 243 WP_000699010.1 phage capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49422.05 Da        Isoelectric Point: 9.1203

>T294745 WP_001125463.1 NZ_OU342919:4107911-4109233 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT294745 WP_001296726.1 NZ_OU342919:4107645-4107911 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9IYX0

Antitoxin

Source ID Structure

References