294739

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3059804..3060429 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag LIX80_RS14800 Protein ID WP_000911329.1
Coordinates 3060031..3060429 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LIX80_RS14795 Protein ID WP_000450524.1
Coordinates 3059804..3060031 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS14770 (3055607) 3055607..3056077 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
LIX80_RS14775 (3056077) 3056077..3056649 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LIX80_RS14780 (3056795) 3056795..3057673 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LIX80_RS14785 (3057690) 3057690..3058724 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
LIX80_RS14790 (3058937) 3058937..3059650 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LIX80_RS14795 (3059804) 3059804..3060031 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LIX80_RS14800 (3060031) 3060031..3060429 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
LIX80_RS14805 (3060576) 3060576..3061439 + 864 WP_001267507.1 neutral zinc metallopeptidase -
LIX80_RS14810 (3061454) 3061454..3063469 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
LIX80_RS14815 (3063543) 3063543..3064241 + 699 WP_000679812.1 esterase -
LIX80_RS14820 (3064322) 3064322..3064522 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T294739 WP_000911329.1 NZ_OU342919:3060031-3060429 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT294739 WP_000450524.1 NZ_OU342919:3059804-3060031 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References