294738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2698922..2699505 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name mazF Uniprot ID U9XFN8
Locus tag LIX80_RS12980 Protein ID WP_000254745.1
Coordinates 2699170..2699505 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag LIX80_RS12975 Protein ID WP_000581937.1
Coordinates 2698922..2699170 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS12965 (2695261) 2695261..2696562 + 1302 WP_000046790.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
LIX80_RS12970 (2696610) 2696610..2698844 + 2235 WP_000226815.1 GTP pyrophosphokinase -
LIX80_RS12975 (2698922) 2698922..2699170 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LIX80_RS12980 (2699170) 2699170..2699505 + 336 WP_000254745.1 endoribonuclease MazF Toxin
LIX80_RS12985 (2699576) 2699576..2700367 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
LIX80_RS12990 (2700595) 2700595..2702232 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
LIX80_RS12995 (2702320) 2702320..2703618 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12158.08 Da        Isoelectric Point: 8.4777

>T294738 WP_000254745.1 NZ_OU342919:2699170-2699505 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT294738 WP_000581937.1 NZ_OU342919:2698922-2699170 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYM3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LMB4

References