294737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2554573..2555227 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag LIX80_RS12320 Protein ID WP_000244777.1
Coordinates 2554820..2555227 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LIX80_RS12315 Protein ID WP_000354046.1
Coordinates 2554573..2554839 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS12290 (2549861) 2549861..2550604 + 744 WP_000951948.1 SDR family oxidoreductase -
LIX80_RS12295 (2550661) 2550661..2552094 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
LIX80_RS12300 (2552139) 2552139..2552450 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
LIX80_RS12305 (2552614) 2552614..2553273 + 660 WP_000250274.1 hemolysin III family protein -
LIX80_RS12310 (2553350) 2553350..2554330 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LIX80_RS12315 (2554573) 2554573..2554839 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LIX80_RS12320 (2554820) 2554820..2555227 + 408 WP_000244777.1 protein YgfX Toxin
LIX80_RS12325 (2555267) 2555267..2555788 - 522 WP_001055874.1 flavodoxin FldB -
LIX80_RS12330 (2555900) 2555900..2556796 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LIX80_RS12335 (2556821) 2556821..2557531 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LIX80_RS12340 (2557537) 2557537..2559270 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T294737 WP_000244777.1 NZ_OU342919:2554820-2555227 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT294737 WP_000354046.1 NZ_OU342919:2554573-2554839 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References