294735

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1984702..1985502 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag LIX80_RS09465 Protein ID WP_000342449.1
Coordinates 1984975..1985502 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag LIX80_RS09460 Protein ID WP_001277108.1
Coordinates 1984702..1984968 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS09440 (1980360) 1980360..1981028 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
LIX80_RS09445 (1981021) 1981021..1982079 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
LIX80_RS09450 (1982324) 1982324..1983178 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
LIX80_RS09455 (1983449) 1983449..1984552 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LIX80_RS09460 (1984702) 1984702..1984968 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LIX80_RS09465 (1984975) 1984975..1985502 + 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LIX80_RS09470 (1985499) 1985499..1985882 - 384 WP_000778785.1 aspartate 1-decarboxylase autocleavage activator PanM -
LIX80_RS09475 (1986306) 1986306..1987415 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LIX80_RS09480 (1987463) 1987463..1988389 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LIX80_RS09485 (1988386) 1988386..1989663 + 1278 WP_047659341.1 branched chain amino acid ABC transporter permease LivM -
LIX80_RS09490 (1989660) 1989660..1990427 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T294735 WP_000342449.1 NZ_OU342919:1984975-1985502 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT294735 WP_001277108.1 NZ_OU342919:1984702-1984968 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A829CN24

References