Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1963412..1963998 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag LIX80_RS09340 Protein ID WP_042014162.1
Coordinates 1963412..1963642 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag LIX80_RS09345 Protein ID WP_000593555.1
Coordinates 1963639..1963998 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS09330 (1959449) 1959449..1962184 + 2736 WP_113441165.1 ribosome-associated ATPase/putative transporter RbbA -
LIX80_RS09335 (1962184) 1962184..1963308 + 1125 WP_001314210.1 ABC transporter permease -
LIX80_RS09340 (1963412) 1963412..1963642 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
LIX80_RS09345 (1963639) 1963639..1963998 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LIX80_RS09350 (1964118) 1964118..1964519 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
LIX80_RS09355 (1964525) 1964525..1965331 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
LIX80_RS09360 (1965328) 1965328..1966092 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
LIX80_RS09365 (1966092) 1966092..1966925 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
LIX80_RS09370 (1966922) 1966922..1967866 - 945 WP_032254808.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T294734 WP_042014162.1 NZ_OU342919:1963412-1963642 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT294734 WP_000593555.1 NZ_OU342919:1963639-1963998 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References