Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 1215670..1216167 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LIX80_RS05930 Protein ID WP_001173343.1
Coordinates 1215670..1215843 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LIX80_RS05935 Protein ID WP_000398619.1
Coordinates 1215871..1216167 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS05920 (1212340) 1212340..1213797 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
LIX80_RS05925 (1214034) 1214034..1215551 + 1518 WP_001295087.1 lysine--tRNA ligase -
LIX80_RS05930 (1215670) 1215670..1215843 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LIX80_RS05935 (1215871) 1215871..1216167 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LIX80_RS05940 (1216394) 1216394..1216666 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LIX80_RS05945 (1216678) 1216678..1216908 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
LIX80_RS05950 (1217089) 1217089..1218720 + 1632 WP_113441013.1 sensor histidine kinase -
LIX80_RS05955 (1218717) 1218717..1219436 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T294732 WP_001173343.1 NZ_OU342919:c1215843-1215670 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT294732 WP_000398619.1 NZ_OU342919:c1216167-1215871 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References