294731

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1111851..1112446 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LIX80_RS05410 Protein ID WP_000239579.1
Coordinates 1111851..1112201 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LIX80_RS05415 Protein ID WP_001223208.1
Coordinates 1112195..1112446 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS05390 (1107297) 1107297..1108319 - 1023 WP_001296689.1 ABC transporter permease -
LIX80_RS05395 (1108333) 1108333..1109835 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
LIX80_RS05400 (1109975) 1109975..1110931 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LIX80_RS05405 (1111241) 1111241..1111771 + 531 WP_000055072.1 inorganic diphosphatase -
LIX80_RS05410 (1111851) 1111851..1112201 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LIX80_RS05415 (1112195) 1112195..1112446 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LIX80_RS05420 (1112658) 1112658..1112999 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LIX80_RS05425 (1113002) 1113002..1116781 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T294731 WP_000239579.1 NZ_OU342919:c1112201-1111851 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT294731 WP_001223208.1 NZ_OU342919:c1112446-1112195 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References