294730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1059730..1061065 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name sanaT Uniprot ID F4VMR9
Locus tag LIX80_RS05175 Protein ID WP_000342497.1
Coordinates 1059730..1060677 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID E0J2C6
Locus tag LIX80_RS05180 Protein ID WP_000152741.1
Coordinates 1060670..1061065 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS05145 (1055583) 1055583..1056299 + 717 WP_001295734.1 N-acetylneuraminic acid outer membrane channel NanC -
LIX80_RS05150 (1056319) 1056319..1057425 + 1107 WP_001298927.1 N-acetylneuraminate epimerase -
LIX80_RS05155 (1057490) 1057490..1058470 + 981 WP_000991446.1 sialate O-acetylesterase -
LIX80_RS05160 (1058478) 1058478..1059128 - 651 WP_001037963.1 HNH endonuclease -
LIX80_RS05165 (1059265) 1059265..1059408 + 144 Protein_1003 HNH endonuclease -
LIX80_RS05170 (1059507) 1059507..1059692 + 186 WP_000066585.1 hypothetical protein -
LIX80_RS05175 (1059730) 1059730..1060677 - 948 WP_000342497.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LIX80_RS05180 (1060670) 1060670..1061065 - 396 WP_000152741.1 DUF6088 family protein Antitoxin
LIX80_RS05185 (1061135) 1061135..1061968 - 834 WP_001192742.1 DUF4942 domain-containing protein -
LIX80_RS05190 (1062444) 1062444..1063606 + 1163 WP_111961598.1 IS3-like element IS3 family transposase -
LIX80_RS05195 (1063637) 1063637..1065091 + 1455 Protein_1009 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 1050058..1066293 16235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35588.79 Da        Isoelectric Point: 4.9737

>T294730 WP_000342497.1 NZ_OU342919:c1060677-1059730 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14619.93 Da        Isoelectric Point: 11.6915

>AT294730 WP_000152741.1 NZ_OU342919:c1061065-1060670 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5BAQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4ZXD4

References