294728

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 489652..490489 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag LIX80_RS02420 Protein ID WP_000227784.1
Coordinates 489947..490489 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag LIX80_RS02415 Protein ID WP_001297137.1
Coordinates 489652..489963 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS02390 (484672) 484672..485619 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
LIX80_RS02395 (485641) 485641..487632 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
LIX80_RS02400 (487622) 487622..488236 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
LIX80_RS02405 (488236) 488236..488565 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
LIX80_RS02410 (488577) 488577..489467 + 891 WP_000971336.1 heme o synthase -
LIX80_RS02415 (489652) 489652..489963 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
LIX80_RS02420 (489947) 489947..490489 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
LIX80_RS02425 (490545) 490545..491342 - 798 WP_226397351.1 tetratricopeptide repeat protein -
LIX80_RS02430 (491446) 491446..492608 + 1163 WP_111961598.1 IS3-like element IS3 family transposase -
LIX80_RS02435 (492640) 492640..492801 - 162 Protein_468 sel1 repeat family protein -
LIX80_RS02440 (493149) 493149..494513 + 1365 WP_001000978.1 MFS transporter -
LIX80_RS02445 (494641) 494641..495132 - 492 WP_001138904.1 nucleotide binding protein YajQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T294728 WP_000227784.1 NZ_OU342919:489947-490489 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT294728 WP_001297137.1 NZ_OU342919:489652-489963 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References