294727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 455574..456192 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LIX80_RS02250 Protein ID WP_001291435.1
Coordinates 455974..456192 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LIX80_RS02245 Protein ID WP_000344800.1
Coordinates 455574..455948 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS02235 (450663) 450663..451856 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LIX80_RS02240 (451879) 451879..455028 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LIX80_RS02245 (455574) 455574..455948 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LIX80_RS02250 (455974) 455974..456192 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LIX80_RS02255 (456364) 456364..456915 + 552 WP_000102564.1 maltose O-acetyltransferase -
LIX80_RS02260 (457031) 457031..457501 + 471 WP_000136192.1 YlaC family protein -
LIX80_RS02265 (457665) 457665..459215 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LIX80_RS02270 (459257) 459257..459610 - 354 WP_000878141.1 DUF1428 family protein -
LIX80_RS02280 (459989) 459989..460300 + 312 WP_000409911.1 MGMT family protein -
LIX80_RS02285 (460331) 460331..460903 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T294727 WP_001291435.1 NZ_OU342919:455974-456192 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT294727 WP_000344800.1 NZ_OU342919:455574-455948 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References