Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4640256..4641937 Replicon chromosome
Accession NZ_OU342706
Organism Klebsiella pneumoniae strain Kp1 isolate Kp1

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag KXF33_RS22765 Protein ID WP_019724882.1
Coordinates 4640256..4641173 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag KXF33_RS22770 Protein ID WP_004177809.1
Coordinates 4641179..4641937 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXF33_RS22745 (KP1VIM_04518) 4635562..4637082 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
KXF33_RS22750 (KP1VIM_04519) 4637079..4638077 + 999 WP_002885172.1 ribose ABC transporter permease -
KXF33_RS22755 (KP1VIM_04520) 4638108..4639049 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
KXF33_RS22760 (KP1VIM_04521) 4639124..4640131 + 1008 WP_015959270.1 carbohydrate kinase family protein -
KXF33_RS22765 (KP1VIM_04522) 4640256..4641173 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KXF33_RS22770 (KP1VIM_04523) 4641179..4641937 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
KXF33_RS22775 (KP1VIM_04524) 4642023..4642751 - 729 WP_002885152.1 response regulator transcription factor -
KXF33_RS22780 (KP1VIM_04527) 4643024..4645171 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
KXF33_RS22785 (KP1VIM_04528) 4645401..4646087 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T294720 WP_019724882.1 NZ_OU342706:c4641173-4640256 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT294720 WP_004177809.1 NZ_OU342706:c4641937-4641179 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References