Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4477023..4477539 Replicon chromosome
Accession NZ_OU342706
Organism Klebsiella pneumoniae strain Kp1 isolate Kp1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KXF33_RS21950 Protein ID WP_004178374.1
Coordinates 4477023..4477307 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KXF33_RS21955 Protein ID WP_002886901.1
Coordinates 4477297..4477539 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXF33_RS21925 (KP1VIM_04356) 4472440..4472748 - 309 WP_019725542.1 PTS sugar transporter subunit IIB -
KXF33_RS21930 4472833..4473006 + 174 WP_019725541.1 hypothetical protein -
KXF33_RS21935 (KP1VIM_04357) 4473009..4473752 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KXF33_RS21940 (KP1VIM_04358) 4474109..4476247 + 2139 WP_019725540.1 anaerobic ribonucleoside-triphosphate reductase -
KXF33_RS21945 (KP1VIM_04359) 4476555..4477019 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KXF33_RS21950 (KP1VIM_04360) 4477023..4477307 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXF33_RS21955 (KP1VIM_04361) 4477297..4477539 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KXF33_RS21960 (KP1VIM_04362) 4477617..4479527 - 1911 WP_019725539.1 PRD domain-containing protein -
KXF33_RS21965 (KP1VIM_04363) 4479550..4480704 - 1155 WP_004178372.1 lactonase family protein -
KXF33_RS21970 (KP1VIM_04364) 4480771..4481511 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T294719 WP_004178374.1 NZ_OU342706:c4477307-4477023 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT294719 WP_002886901.1 NZ_OU342706:c4477539-4477297 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References